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KMID : 0617319940040010123
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Journal of Pharmacetical Sceiences Ewha Womans University
1994 Volume.4 No. 1 p.123 ~ p.128
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STEREOCHEMICAL APPROACH FOR ENZYME INHIBITOR DESIGN
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Kim Dong-H.
Zhi-Hong Li
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Abstract
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Inhibitors of α-chymotrypsin have been designed on the basis of the recently proposed three dimensional active site model of the enzyme. Thus, (2S, 3R)-2-benzyl-3,4-epoxybutanoic acid (BEBA) methyl ester inactivated the enzyme irreversibly, while (25, 3S)-BEBA methyl ester inhibited the enzyme competitively. The other two stereoisomers are substrates for the enzyme, forming respective BEBA upon the treatment with the enzyme.
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KEYWORD
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